Actually, I'm not trying to recall a whole comic, exactly. I'm pretty sure I know of the comic itself, but...
I recall a particular page, a particular gag, and I can't recall what webcomic I read it in.
Some folks were playing a Street Fighter game, or possibly a Capcom Vs game. The joke goes something along the lines that one person kept getting beaten, and the other person was blaming it on the fact that he (she?) kept choosing girl characters, when he (she?) would do much better with a male character. (This part I'm a little fuzzy on, but I recall the punchline quite well.)
So the person selects a male character, and then... gets beaten even worse. The second guy responds "Yeah, Dan is... different."
I can think of a dozen different comics this could be; most likely it was a gaming comic, but there is nothing specific to any characters in this gag, and I don't recall a visual style so... I can't recall where I read it.
My webcomic: Mischief in Maytia