I help out a friend by doing the techie stuff. We started off with ComicPress, but on a whim I downloaded and started playing with Easel today.
It's pretty nice. I think it's learning curve is pretty big though, even coming from ComicPress.
@Justinfh: You can. I made mine 980px. Its in various spots in style.css. #page, body.layout-2cl #page, body.layout-2cr #page, #page_foot.
I got fed up with the editor pretty fast and just ended up pulling style.css and default-style.css into two blank files in Programmers Notepad and edited them there then just copied them back into the wordpress editor.