I'm kind of curious (not that you need to tell us) why you fixated on this particular video game. As Clint says, you could go almost anywhere storywise with this, depending on how you treat it. Jokewise, I think you'll run out of decent material after a few updates.
I think you'd probably be better off with a more generic comic based on platform games in general (Lode Runner, Pitfall, Super Mario, etc.). And while the game is old, and the while IP owners probably don't mind you basing a comic off their work, I can't imagine that they would give you official permission to do it for various technical, legal, and artistic reasons.
To be honest, I doubt you'd get much serious following because of the brand name itself. I don't think I've ever even heard of the game before. You are probably severely minimizing your audience, if that's why you are choosing this particular game. If you're trying to get your popularity count up, go with Zelda, Mario, Final Fantasy, Team Fortress, or some other Mega-hit game. Heck, Halo threw in that awesome theater system just so people could make derivative fan works (ala Red Vs Blue).
All that said, do what you enjoy doing.